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KMID : 1102220230420020166
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Kidney Research and Clinical Practice
2023 Volume.42 No. 2 p.166 ~ p.173
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Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
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Choi Sung-Eun
Agnes B. Fogo
Lim Beom-Jin
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Abstract
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The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification for lupus nephritis adopted the most recent NIH indices to replace subclasses A, C, and A/C. Although an evidence-based approach should further evaluate the clinical significance of the modified NIH indices, recent validation studies demonstrated that the modified chronicity indices have a strong correlation with kidney outcome of lupus nephritis.
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KEYWORD
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Biopsy, Lupus nephritis, Prognosis, Treatment outcome
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